HCID 54305220, compound → HCID 178460932, compound

Participants

Reaction Steps

20.0 ml (30.0 mmol) of a tetrahydrofuran solution of 1.5M p-fluorophenylethynyl magnesium chloride was dripped into a mixture of 3.50 g (10.8 mmol) of 4-(2-(p-bromophenyl) ethyl)-1-n-propyl-1-silacyclohexane, 80 mg of tetrakis (triphenylphosphine) palladium (0) and 20 ml of tetrahydrofuran. The reaction mixture was stirred for 8 hours at room temperature. After a conventional after treatment, purification was conducted by means of silica-gel column chromatography to obtain 2.87 g (yield 73%) of the target product.

Provenance & Evidence