HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 2-(benzenesulfonyl)-3-ethoxyprop-2-enenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Phenylsulphonylacetonitrile | HCID 82077 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(benzenesulfonyl)-3-ethoxyprop-2-enenitrile | HCID 5177559 | 78% |
Reaction Steps
A solution of (phenylsulfonyl)acetonitrile (10.5 g, 0.089 mol) in triethyl orthoformate (21 mL, 0.14 mol) and acetic anhydride (21 mL, 0.2 mol) was heated at 160° C. with removal of ethyl acetate (35 mL). The dark oily residue was dissolved in methanol (60 mL) and the solution was concentrated and recrystallized from hexanes/ethyl acetate to yield (11.98 g, 78%) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05545515 |
| Source dataset | uspto-grants-1996_08 |
| ORD ID | ord-89762a37df2941d59d2cc293b7d3df3f |
| Source note | uspto-grants-1996_08 |