HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1077898Generated: October 31, 2026
N-chloroacetyl-N-ethoxycarbonylmethyl-4-(2,2,3,3-tetrafluoropropoxy)aniline → 1-[4-(2,2,3,3-Tetrafluoropropoxy)phenyl]-2,5-piperazinedione
https://huagongshe.com/reaction/1077898
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-chloroacetyl-N-ethoxycarbonylmethyl-4-(2,2,3,3-tetrafluoropropoxy)aniline | HCID 19065094 | — |
| Reactant | Ethanol, reaction products with ammonia, distn. residues | HCID 22020343 | — |
| Product | 1-[4-(2,2,3,3-Tetrafluoropropoxy)phenyl]-2,5-piperazinedione | HCID 19065120 | — |
Reaction Steps
The resulting N-chloroacetyl-N-ethoxycarbonylmethyl-4-(2,2,3,3-tetrafluoropropoxy)aniline (1.9 g) was dissolved in 20 ml of 10.5% ammonia-ethanol and the solution was stirred at 60° C. for four hours. After cooling, the crystals separated out therefrom were collected by filtration and washed with cold ethanol to give 1.5 g of 1-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2,5-piperazinedione as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05545652 |
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| Source dataset | uspto-grants-1996_08 |
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| ORD ID | ord-1dd724f3934f4036837f7f0a3e6e494b |
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| Source note | uspto-grants-1996_08 |
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