Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → t-butyl [N-benzyloxycarbonyl-4-piperidinyloxy]acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | tert-Butyl bromoacetate | HCID 79177 | — |
| 반응물 | Benzyl 4-Hydroxy-1-piperidinecarboxylate | HCID 2794620 | — |
| 촉매 | Tetrabutylammonium hydrogen sulfate | HCID 94433 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | t-butyl [N-benzyloxycarbonyl-4-piperidinyloxy]acetate | HCID 10066408 | — |
반응 단계
28 ml of t-butyl bromoacetate and 1.4 g of tetra-n-butylammonium hydrogen sulphate in 10 ml of water are added to a solution of 30.1 g of N-benzyloxycarbonyl-4-hydroxy-piperidine in 300 ml of toluene. Thereafter, a solution of 125 g of sodium hydroxide in 125 ml of water is added dropwise thereto. After stirring overnight, the organic extracts are separated, dried and concentrated. After drying there are obtained 34.1 g of N-benzyloxycarbonyl-4-[(t-butoxy carbonyl) methoxy]-piperidine, Rf =0.76 (ethyl acetate). MS (EI): 293 (M--C4H8)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05545658 |
| 출처 데이터셋 | uspto-grants-1996_08 |
| ORD ID | ord-5069f8be58bf41bbbc2fd4e5525d47d5 |
| 출처 메모 | uspto-grants-1996_08 |