HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → Benzyl [[[4-[(t-butoxycarbonyl)methoxy]piperidinyl]carbonyl]methyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Benzyloxycarbonylglycine | HCID 14349 | — |
| Reactant | Tert-butyl (piperidin-4-yloxy)-acetate | HCID 10036224 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Benzyl [[[4-[(t-butoxycarbonyl)methoxy]piperidinyl]carbonyl]methyl]carbamate | HCID 10341285 | 88.7% |
Reaction Steps
5.8 g of Z-glycine are first activated with 5.4 g of CDMT and then coupled with 6.0 g of t-butyl 4-piperidinyloxyacetate and 6.3 ml of N-methylmorpholine in dichloromethane there are obtained 10 g of benzyl [[[4-[(t-butoxycarbonyl)methoxy]piperidinyl]carbonyl]methyl]carbamate. MS (EI): 406 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05545658 |
| Source dataset | uspto-grants-1996_08 |
| ORD ID | ord-7bcade2f077144b09d10bf0f47181b14 |
| Source note | uspto-grants-1996_08 |