HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetate → Lamifiban
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetate | HCID 175 | — |
| Reactant | Trifluoroacetate | HCID 84468 | — |
| Reactant | HCID 10257638 | HCID 10257638 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | Lamifiban | HCID 3038484 | — |
Reaction Steps
From 2.5 g of the acetate of t-butyl [[1-[N-(p-amidinobenzoyl)-3-(p-t-butoxyphenyl)-L-alanyl]-4-piperidinyl]oxy]-acetate there is obtained in analogy to Example 1, after chromatography (silylated silica get RP-18, water/methanol gradient), 1.0 g of [[1-[N-(p-amidinobenzoyl)-L-tyrosyl]-4-piperidinyl]oxy]acetic acid as the trifluoroacetate. M.p. 125°-130° C. (ethyl acetate, decomposition). MS (FAB): 469 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05545658 |
| Source dataset | uspto-grants-1996_08 |
| ORD ID | ord-0ffcbfaf16f7431ea671799714f736db |
| Source note | uspto-grants-1996_08 |