反应详情

To a solution of 1-N-(1-benzyl-piperidin-4-yl)-indole (100 g, 0.344 mol) in methylene chloride (1 L) was added ethyl chloroformate (99.2 mL) dropwise with stirring. The mixture was refluxed for 48 hours, cooled to room temperature, and concentrated. The residue was crystallized from i-propanol to give the title compound as colorless crystals (50 g, 53% yield). M. Pt.: 127° C.

1. temperatureThe mixture was refluxed for 48 hours
2. concentrationconcentrated
3. customThe residue was crystallized from i-propanol