3,5-Bis(trifluoromethyl)benzenesulphonyl chloride → Benzhydrol 2-[2-(octylsulfonamido)phenoxy]benzoate

Participants

Reaction Steps

Following the procedure of Example 1(e) except substituting benzhydrol 2-(2-aminophenoxy)benzoate for benzhydrol 2-(2-amino-4-trifluoromethylphenoxy)benzoate and substituting 1-octanesulfonyl chloride for 3,5-bis(trifluoromethyl)benzenesulfonyl chloride, the title compound was obtained as a white solid. 1H NMR (250 MHz, CDCl3) δ8.01 (dd, 1H), 7.64 (dd, 1H), 7.47-7.52 (m, 2H), 7.00-7.33 (m, 14H), 6.85 (dd, 1H), 6.53 (dd, 1H), 2.88-2.95 (m, 2H), 1.65-1.69 (m, 2H), 1.18-1.25 (m, 10H), 0.85 (t, 3H).

Provenance & Evidence