Potassium Carbonate → HCID 13409498, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-hydroxyphenylacetic acid (1.52 g, 0.01 mol), 4-fluoro-3-nitrobenzotrifluoride (2.09 g, 0.01 mol), potassium carbonate (2.76 g, 0.02 mol) in dimethylformamide (10 mL) was heated at 95° C. 16 h. The solvent was evaporated, the residue was acidified with dilute HCl, extracted with EtOAc, dried over anhydrous sodium sulfate, filtered and evaporated. The crude product was purified by flash chromatography (silica gel, ethyl acetate/hexane/formic acid). Recrystallization from EtOAc/hexane gave the title compound; mp 165°-167° C.

Provenance & Evidence