Levofloxacin → Levofloxacin monohydrate

Participants

Reaction Steps

A further aspect of the present invention comprises treating (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid in an aqueous solvent of relatively high water content or water to produce (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid monohydrate. Here, the solvent has a water content which substantially prevents hemihydrate formation. The aqueous solvent is preferably aqueous ethanol.

Provenance & Evidence