Levofloxacin → Levofloxacin monohydrate

Participants

Reaction Conditions

Reaction Steps

5 g of crude levofloxacine crystals were added to 25 ml of water and formulated into a slurry. The obtained slurry was stirred at 25° C. for 20 hours. The crystals were collected by filtering, washed with 5 ml of water and dried at room temperature under reduced pressure. When a constant weight was achieved, 4.76 g of (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid monohydrate was obtained. The analysis on these crystals by the powdery method of X-ray diffraction proved that the product was the monohydrate.

Provenance & Evidence