反应详情

A reaction vessel was charged with 140 g of thionyl chloride and 100 ml of benzene, and 100 g of 3-pentylcyclobutanecarboxylic acid was added dropwise under reflux with stirring. The resultant mixture was refluxed with stirring for 8 hours and the excess thionyl chloride was azeotropically distilled off with benzene and the residue was distilled under reduced pressure to obtain 101 g (yield 91%) of 3-pentylcyclobutanecarboxylic acid chloride.

1. additionwas added dropwise
2. temperatureunder reflux
3. stirringwith stirring for 8 hours
4. distillationthe excess thionyl chloride was azeotropically distilled off with benzene
5. distillationthe residue was distilled under reduced pressure