3,3'-Difluoro-4-hydroxy-4'-octyloxybiphenyl → 3-Octylcyclobutanecarboxylic acid chloride

Participants

Reaction Steps

Except that 0.60 g of the crude 3,3 '-difluoro-4-hydroxy-4'-octyloxybiphenyl obtained in Example 5- (c) was used in place of 0.7 g of the crude 3,3'-difluoro-4-hydroxy-4'-decyloxybiphenyl and 0.4 g of the crude trans-3-pentylcyclobutanecarboxylic acid chloride obtained in (d) above in place of 0.5 g of the 3-octylcyclobutanecarboxylic acid chloride used in Example 9-(g) and purification was carried out by way of column chromatography on silica gel (eluent: hexane/benzene=2/1), the operation was performed in the same manner as in Example 9-(g) to obtain 0.84 g (yield 91.1%) of 3,3'-difluoro-4-octyloxybiphenyl-4'-yl trans-3-pentylcyclobutanecarboxylate.

Provenance & Evidence