3,3'-Difluoro-4-hydroxy-4'-octyloxybiphenyl → 3-Octylcyclobutanecarboxylic acid chloride
Reaction equation
F[C:2]1[CH:3]=C(C2C=CC(OCCCCCCCC)=C(F)C=2)C=C[C:7]=1O.[CH2:25]([C@@H:30]1[CH2:33][C@H:32]([C:34]([Cl:36])=[O:35])[CH2:31]1)[CH2:26][CH2:27][CH2:28][CH3:29]>>[CH2:25]([CH:30]1[CH2:31][CH:32]([C:34]([Cl:36])=[O:35])[CH2:33]1)[CH2:26][CH2:27][CH2:28][CH2:29][CH2:7][CH2:2][CH3:3]Participants
3
Procedure
Except that 0.60 g of the crude 3,3'-difluoro-4-hydroxy-4'-octyloxybiphenyl obtained in Example 5-(c) was used in place of 0.7 g of the crude 3,3'-difluoro-4-hydroxy-4'-decyloxybiphenyl and 0.4 g of cis-3-pentylcyclobutanecarboxylic acid chloride obtained in (b) above in place of 0.5 g of the 3-octylcyclobutanecarboxylic acid chloride used in Example 9-(g) and purification was carried out by way of column chromatography on silica gel (eluent: hexane/benzene=2/1), the operation was performed in the same manner as in Example 9-(g) to obtain 0.58 g (yield 63.3%) of 3,3'-difluoro-4-octyloxybiphenyl-4'-yl cis-3-pentylcyclobutanecarboxylate.
Sources & evidence
- ORD record
- ord-8401d94e57124556a540d6bbc0c2da8b
- Source dataset
- uspto-grants-1996_08
- Patent number
- US05545747
Reaction notes
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