HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 18331844, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Dipropylamine | HCID 8902 | — |
| Reactant | 3-Phenylpropylamine | HCID 16259 | — |
| Reactant | 7-Oxo-5,6,7,8-tetrahydronaphthalene-1-sulfonamide | HCID 18331746 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 18331844 | HCID 18331844 | 99.3% |
Reaction Steps
The compound was prepared in a manner similar to the preparation of the dipropylamine above using 8-aminosulfonyl-2-tetralone (1.13 g, 5.0 mmol), 3-phenyl-1-propylamine (0.75 ml, 5.3 mmol), p-toluenesulfonic acid (0.10 g, 0.53 mmol), and platinum oxide (0.30 g) in benzene (20 mls) and ethanol (35 mls) to give a solid (1.71 g). The compound was crystallized from acetonitrile and converted to the hydrochloride salt as above. (m.p. 105°-130° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05545755 |
| Source dataset | uspto-grants-1996_08 |
| ORD ID | ord-a539800b605646cba5ab05d8b89304bf |
| Source note | uspto-grants-1996_08 |