benzyl N-[(1S)-3-amino-1-[[1-benzyl-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenyl-butyl]carbamoyl]-3-oxo-propyl]carbamate → 2-Amino-4-(Cbz-asparaginyl-amino)-1,5-diphenyl-3-hydroxypentane

Participants

Reaction Steps

Using the procedure of Example 11 with the resultant compound of Example 66 gave, after silica gel chromatography using methanol/isopropylamine/chloroform, the desired compound (RF 0.3; 2.5% methanol/2% isopropylamine/chloroform) in 95% yield. Mass spectrum (M+H)+ =519.

Provenance & Evidence