HRID1078112

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75314

L-Asparagine, N2-[(phenylmethoxy)carbonyl]-

C12H14N2O5

结构：CC(C)(C)OC(=O)NC(Cc1ccccc1)C(O)C(N)Cc1ccccc1

HCID14704377

未命名化合物

结构：NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(O)C(N)Cc1ccccc1

HCID22845587

未命名化合物

PRODUCTS

生成物

结构：NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(O)C(Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1

HCID3011025

未命名化合物

收率 75%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21584188

Chloroform methanol

C2H5Cl3O

PROCEDURE

实验过程

Using the procedure of Example 55 but replacing Cbz-Val-OH with Cbz-Asn-OH and replacing the resultant compound of Example 11 with the resultant compound of Example 67 gave, after silica gel chromatography using methanol/chloroform, the desired compound (RF 0.4; 2.5% methanol/2% isopropylamine/chloroform) in 75% yield, m.p. 234°-236° C. (dec). Mass spectrum (M+H)+ =767.

WORKUP

后处理

customgave

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0c8639d0d17546a990f3de3895904a03
来源数据集: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05545750
来源说明: uspto-grants-1996_08

反应 SMILES

[NH:1]([C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11])[C@H:2]([C:7](O)=[O:8])[CH2:3][C:4](=[O:6])[NH2:5].NC(CC1C=CC=CC=1)C(O)C(NC(OC(C)(C)C)=O)CC1C=CC=CC=1.[NH2:47][CH:48]([CH:56]([OH:84])[CH:57]([NH:65][C:66](=[O:83])[C@H:67]([CH2:79][C:80](=[O:82])[NH2:81])[NH:68][C:69]([O:71][CH2:72][C:73]1[CH:78]=[CH:77][CH:76]=[CH:75][CH:74]=1)=[O:70])[CH2:58][C:59]1[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=1)[CH2:49][C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1>CO.C(Cl)(Cl)Cl>[C:69]([NH:68][C@H:67]([C:66]([NH:65][CH:57]([CH:56]([OH:84])[CH:48]([NH:47][C:7](=[O:8])[C@H:2]([CH2:3][C:4](=[O:6])[NH2:5])[NH:1][C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11])[CH2:49][C:50]1[CH:51]=[CH:52][CH:53]=[CH:54][CH:55]=1)[CH2:58][C:59]1[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=1)=[O:83])[CH2:79][C:80](=[O:82])[NH2:81])([O:71][CH2:72][C:73]1[CH:78]=[CH:77][CH:76]=[CH:75][CH:74]=1)=[O:70]