HRID1078120

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID160435

Methanediimine

CH2N2

结构：Cc1ccc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)cc1

HCID2249310

未命名化合物

结构：Cc1ccc(S(=O)(=O)N[C@H](C(=O)NC(Cc2ccccc2)C(O)C(N)Cc2ccccc2)C(C)C)cc1.Cl

HCID22845588

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)N[C@H](C(=O)NC(Cc2ccccc2)C(O)C(Cc2ccccc2)NC(=O)[C@@H](NS(=O)(=O)c2ccc(C)cc2)C(C)C)C(C)C)cc1

HCID22845570

未命名化合物

PROCEDURE

实验过程

According to the carbodiimide coupling procedure of Example 55, N-(p-toluenesulfonyl)valine was coupled to the resultant compound of Example 112 to give the desired compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eab71a3846944dd19228f4cdbf105348
来源数据集: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05545750
来源说明: uspto-grants-1996_08

反应 SMILES

N=C=N.[C:4]1([CH3:21])[CH:9]=[CH:8][C:7]([S:10]([NH:13][C@H:14]([C:18](O)=[O:19])[CH:15]([CH3:17])[CH3:16])(=[O:12])=[O:11])=[CH:6][CH:5]=1.Cl.[NH2:23][CH:24]([CH:32]([OH:59])[CH:33]([NH:41][C:42](=[O:58])[C@H:43]([CH:55]([CH3:57])[CH3:56])[NH:44][S:45]([C:48]1[CH:53]=[CH:52][C:51]([CH3:54])=[CH:50][CH:49]=1)(=[O:47])=[O:46])[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[C:51]1([CH3:54])[CH:52]=[CH:53][C:48]([S:45]([NH:44][C@H:43]([C:42]([NH:41][CH:33]([CH:32]([OH:59])[CH:24]([NH:23][C:18](=[O:19])[C@H:14]([CH:15]([CH3:17])[CH3:16])[NH:13][S:10]([C:7]2[CH:8]=[CH:9][C:4]([CH3:21])=[CH:5][CH:6]=2)(=[O:12])=[O:11])[CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)=[O:58])[CH:55]([CH3:57])[CH3:56])(=[O:46])=[O:47])=[CH:49][CH:50]=1