Carbodiimide → HCID 22864440, compound

HRID 1078123Notes

Reaction equation

N=[C:2]=[NH:3].Cl.Cl.[NH2:6][CH:7]([CH:15]([OH:43])[CH:16]([NH:24][C:25](=[O:42])[C@H:26]([CH:39]([CH3:41])[CH3:40])[NH:27][S:28](=[O:38])(=[O:37])[NH:29][N:30]1[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]1)[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[CH3:36][N:33]1[CH2:32][CH2:31][N:30]([NH:29][S:28]([NH:27][C@H:26]([C:25]([NH:24][CH:16]([CH:15]([OH:43])[CH:7]([NH:6][C:25](=[O:42])[C@H:26]([CH:39]([CH3:40])[CH3:41])[NH:27][S:28](=[O:37])(=[O:38])[NH:29][N:30]2[CH2:31][CH2:32][N:3]([CH3:2])[CH2:34][CH2:35]2)[CH2:8][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:17][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[O:42])[CH:39]([CH3:41])[CH3:40])(=[O:37])=[O:38])[CH2:35][CH2:34]1

Participants

Reactant 2

HCID 160435Carbodiimide

HCID 22864447HCID 22864447, compound

Product 1

HCID 22864440HCID 22864440, compound

Procedure

According to the carbodiimide coupling procedure of Example 55, the resultant compound of Example 137B was coupled to the resultant compound of Example 138 to give the desired compound.

Sources & evidence

ORD record: ord-9ddc7b8239714a708586aec71694d00b
Source dataset: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05545750

Reaction notes

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