HRID1078132

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1

HCID112124

4-Nitrophenyl N-((benzyloxy)carbonyl)-L-valinate

C19H20N2O6

结构：N[C@@H](Cc1ccccc1)[C@H](O)[C@@H](O)[C@@H](N)Cc1ccccc1

HCID10979512

未命名化合物

PRODUCTS

生成物

结构：CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C

HCID452454

Bis((Cbz-Val-Phe-psi(CHOH))

C44H54N4O8

收率 5%

PROCEDURE

实验过程

Cbz-valine p-nitrophenyl ester was coupled to (2S,3S,4S,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane using the procedure of Example 172B to provide the desired compound (Rf 0.42, 5% methanol in chloroform) as a white solid, m.p. 239°-242° C. in 86% yield.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-962e617b252e486ca6b3531629ed4d96
来源数据集: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05545750
来源说明: uspto-grants-1996_08

反应 SMILES

[N+](C1C=CC(O[C:11](=[O:27])[C@H:12]([CH:24]([CH3:26])[CH3:25])[NH:13][C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])=CC=1)([O-])=O.[NH2:28][C@H:29]([C@H:37]([OH:49])[C@@H:38]([OH:48])[C@@H:39]([NH2:47])[CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)[CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[C:14]([NH:13][C@H:12]([C:11]([NH:28][C@H:29]([C@H:37]([OH:49])[C@@H:38]([OH:48])[C@@H:39]([NH:47][C:11](=[O:27])[C@H:12]([CH:24]([CH3:25])[CH3:26])[NH:13][C:14]([O:16][CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:15])[CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)[CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:27])[CH:24]([CH3:26])[CH3:25])([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15]