HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(Boc-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Boc-L-Valine | HCID 83693 | — |
| Reactant | Carbodiimide | HCID 160435 | — |
| Reactant | 2Amino-4-(Cbz-valinyl-amino)-1,5-diphenyl-3hydroxypentane | HCID 22864446 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-(Boc-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane | HCID 22845591 | — |
Reaction Steps
Boc-valine was coupled to the resultant compound of Example 69 using the carbodiimide coupling procedure of Example 55 to provide, after silica gel chromatography using 3% methanol in chloroform, the desired compound (82%, Rf 0.7, 10% methanol in chloroform) as a white solid, m.p. 184°-184° C. Mass spectrum: (M+H)+ =703.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05545750 |
| Source dataset | uspto-grants-1996_08 |
| ORD ID | ord-e6a60cf613c5427883032e748022c780 |
| Source note | uspto-grants-1996_08 |