HRID1078137

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C

HCID22845591

未命名化合物

PRODUCTS

生成物

结构：CC(C)[C@H](N)C(=O)NC(Cc1ccccc1)C(O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C

HCID22845651

未命名化合物

收率 89%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

Using the procedure of Example 12 with the resultant compound of Example 239 provided a crude hydrochloride salt which was partitioned between chloroform and aqueous NaHCO3, dried over Na2SO4, and concentrated. Chromatography of the residue on silica gel using 3% methanol in chloroform provided in 89% yield the desired compound (Rf 0.5, 10% methanol in chloroform) as a white solid, m.p. 126°-127° C. Mass spectrum: (M+H)+ =603.

WORKUP

后处理

customprovided a crude hydrochloride salt which
customwas partitioned between chloroform and aqueous NaHCO3
dry with materialdried over Na2SO4
concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-01a9756e2dc841f88d7b9d5d7536e062
来源数据集: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05545750
来源说明: uspto-grants-1996_08

反应 SMILES

C([NH:8][C@H:9]([C:13]([NH:15][CH:16]([CH:24]([OH:51])[CH:25]([NH:33][C:34](=[O:50])[C@H:35]([CH:47]([CH3:49])[CH3:48])[NH:36][C:37]([O:39][CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)=[O:38])[CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:14])[CH:10]([CH3:12])[CH3:11])(OC(C)(C)C)=O>C(Cl)(Cl)Cl>[C:37]([NH:36][C@H:35]([C:34]([NH:33][CH:25]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH:24]([OH:51])[CH:16]([NH:15][C:13](=[O:14])[C@H:9]([CH:10]([CH3:12])[CH3:11])[NH2:8])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:50])[CH:47]([CH3:49])[CH3:48])([O:39][CH2:40][C:41]1[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=1)=[O:38]