Indole-2-carboxylic acid → HCID 10259669, compound

HRID 1078147Notes

Reaction equation

HRID 1078147 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([OH:12])=O.[NH2:13][C@H:14]([C:18]([NH:20][C@H:21]([C@@H:29]([OH:48])[C@H:30]([OH:47])[C@@H:31]([NH:39][C:40](=[O:46])[C@H:41]([CH:43]([CH3:45])[CH3:44])[NH2:42])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:19])[CH:15]([CH3:17])[CH3:16].N=[C:50]=[NH:51]>>[NH:51]1[C:50]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([NH:13][C@H:14]([C:18]([NH:20][C@H:21]([C@@H:29]([OH:48])[C@H:30]([OH:47])[C@@H:31]([NH:39][C:40](=[O:46])[C@H:41]([CH:43]([CH3:44])[CH3:45])[NH:42][C:10]([C:2]1[NH:1][C:9]2[C:4]([CH:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2)=[O:12])[CH2:32][C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:19])[CH:15]([CH3:17])[CH3:16])=[O:12]

Participants

4

Reactant 3

HCID 72899Indole-2-carboxylic acidHCID 160435CarbodiimideHCID 10368652HCID 10368652, compound

Product 1

HCID 10259669HCID 10259669, compound

Procedure

Indole-2-carboxylic acid was coupled to the resultant compound of Example 173 using the carbodiimide coupling procedure of Example 55 to provide the desired compound.

Sources & evidence

ORD record
ord-13b3dbff17724a23851d1adceba39ff1
Source dataset
uspto-grants-1996_08
Patent number
US05545750

Reaction notes

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