Trifluoroacetic acid → HCID 22864424, compound

Participants

Reaction Steps

A solution of 310 mg (0.552 mmol) of the intermediate obtained in Step J in 5 mL of ethanol with 0.1 mL of trifluoroacetic acid was hydrogenated at 40 psi and ambient temperature in the presence of 100 mg of 10% palladium on carbon for 4 hours. The mixture was filtered through Celite and solvent removed under vacuum to give the product. 1H NMR (400 MHz, CD3OD): δ2.69 (s, 3H), 3.24 (m, 1H), 3.44 (dd; 6, 16 Hz; 1H), 4.11 (s, 2H), 4.13 (d, 17 Hz, 1H), 4.68 (d, 14 Hz, 1H), 4.86 (d, 14 Hz, 1H), 5.14 (m, 1H), 5.18 (d, 17 Hz, 1H), 6.95 (d, 8 Hz, 1H), 7.07 (t, 8 Hz, 1H), 7.15-7.25 (m, 5H), 7.28 (m, 1H), 7.28 (d, 8 Hz, 2H), 7.33 (t, 8 Hz, 1H), 7.38 (d, 8 Hz, 1H).

Provenance & Evidence