HCID 178455855, compound → HCID 178460941, compound

Participants

Reaction Steps

A mixed solution of 3.7 g (10 mmol) of 1-chloro-4-(2-(trans-4-(3,4-difluorophenyl)cyclohexyl)ethyl)-1-silacyclohexane and 30 ml of tetrahydrofuran (hereafter abbreviated as "THF") was prepared, and a 5 ml THF solution of 2.5M n-propylmagnesium chloride (12.5 mmol) was dripped into this solution. The silacyclohexane rings of the target product thus obtained were a mixture of trans isomers and cis isomers. Following a conventional after treatment, they were separated by means of chromatography to obtain 2.9 g of the trans isomers of the target product (yield 80%). The results of its analysis are shown below.

Provenance & Evidence