HCID 178445887, compound → HCID 178460940, compound

HRID 1078163Notes

Reaction equation

HRID 1078163 reaction equation
Cl[SiH:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][C@H:10]2[CH2:15][CH2:14][C@H:13]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)[CH2:4][CH2:3]1.[Cl-].[CH2:27]([Zn+])[CH2:28][CH3:29].Cl[SiH]1CCC(CC[C@H]2CC[C@H](C3C=CC(F)=CC=3)CC2)CC1.[Cl-].C([Zn+])CCCC>>[F:23][C:22]([F:25])([F:24])[C:19]1[CH:20]=[CH:21][C:16]([C@H:13]2[CH2:14][CH2:15][C@H:10]([CH2:9][CH2:8][C@H:5]3[CH2:6][CH2:7][Si@H:2]([CH2:27][CH2:28][CH3:29])[CH2:3][CH2:4]3)[CH2:11][CH2:12]2)=[CH:17][CH:18]=1

Participants

5

Reactant 4

HCID 178445887HCID 178445887, compoundHCID 178455872HCID 178455872, compoundHCID 178505737HCID 178505737, compoundHCID 178506167HCID 178506167, compound

Product 1

HCID 178460940HCID 178460940, compound

Procedure

The preparation was conducted in the same manner as in Example 6, except that 8.2 g (21 mmol) of 1-chloro-4-(2-(trans-4-(p-trifluoromethylphenyl)cyclohexyl)ethyl)-1-silacyclohexane and n-propylzinc chloride were used instead of 7.0 g (21 mmol) of 1-chloro-4-(2-(trans-4-(p-fluorophenyl)cyclohexyl)ethyl)-1-silacyclohexane and n-pentylzinc chloride.

Sources & evidence

ORD record
ord-d1303c179e5a4b969ef353988ce351ce
Source dataset
uspto-grants-1996_08
Patent number
US05547606

Reaction notes

Loading…