HCID 178445887, compound → HCID 178495612, compound

HRID 1078165Notes

Reaction equation

HRID 1078165 reaction equation
Cl[SiH:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][C@H:10]2[CH2:15][CH2:14][C@H:13]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[C:18]([F:23])[CH:17]=3)[CH2:12][CH2:11]2)[CH2:4][CH2:3]1.[Cl-].[CH3:25][O:26][CH2:27][CH2:28][CH2:29][Zn+].Cl[SiH]1CCC(CC[C@H]2CC[C@H](C3C=CC(F)=CC=3)CC2)CC1.[Cl-].C([Zn+])CCCC>>[F:23][C:18]1[CH:17]=[C:16]([C@H:13]2[CH2:14][CH2:15][C@H:10]([CH2:9][CH2:8][C@H:5]3[CH2:6][CH2:7][Si@H:2]([CH2:29][CH2:28][CH2:27][O:26][CH3:25])[CH2:3][CH2:4]3)[CH2:11][CH2:12]2)[CH:21]=[CH:20][C:19]=1[F:22]

Participants

5

Reactant 4

HCID 178445887HCID 178445887, compoundHCID 178495111HCID 178495111, compoundHCID 178505737HCID 178505737, compoundHCID 178505738HCID 178505738, compound

Product 1

HCID 178495612HCID 178495612, compound

Procedure

The preparation was conducted in the same manner as in Example 6, except that 7.5 g (21 mmol) of 1-chloro-4-(2-(trans-4-(3,4-difluorophenyl)cyclohexyl)ethyl)-1-silacyclohexane and 3-methoxypropylzinc chloride were used instead of 7.0 g (21 mmol) of 1-chloro-4-(2-(trans-4-(p-fluorophenyl)cyclohexyl) ethyl)-1-silacyclohexane and n-pentylzinc chloride.

Sources & evidence

ORD record
ord-d2c15e79827d4f1e80d14e44e6063391
Source dataset
uspto-grants-1996_08
Patent number
US05547606

Reaction notes

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