HCID 178427747, compound → HCID 178447764, compound

HRID 1078168Notes

Reaction equation

HRID 1078168 reaction equation
C1(C)C=CC(S(O[CH2:11][Si@H:12]2[CH2:17][CH2:16][C@H:15]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[CH2:14][CH2:13]2)(=O)=O)=CC=1.[CH2:26]([Si@H:31]1[CH2:36][CH2:35][C@H:34]([CH2:37][Mg]Br)[CH2:33][CH2:32]1)[CH2:27][CH2:28][CH2:29][CH3:30].C1(C)C=CC(S(OC[C@H]2CC[C@H](C3C=CC(F)=CC=3)CC2)(=O)=O)=CC=1.C([Si@H]1CC[C@H](C[Mg]Br)CC1)CC>>[F:24][C:21]1[CH:20]=[CH:19][C:18]([C@H:15]2[CH2:14][CH2:13][Si@H:12]([CH2:11][CH2:37][C@H:34]3[CH2:35][CH2:36][Si@H:31]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:32][CH2:33]3)[CH2:17][CH2:16]2)=[CH:23][CH:22]=1

Participants

5

Reactant 4

HCID 178427747HCID 178427747, compoundHCID 178427797HCID 178427797, compoundHCID 178447778HCID 178447778, compoundHCID 178460953HCID 178460953, compound

Product 1

HCID 178447764HCID 178447764, compound

Procedure

The preparation was conducted in the same manner as in Example 22, except that 18.9 g (50 mmol) of (trans-4-(p-fluorophenyl)-1-silacyclohexyl)methyl p-toluenesulfonate and (trans-4-n-pentyl-4-silacyclohexyl)methylmagnesium bromide were used instead of 18.1 g (50 mmol) of (trans-4-(p-fluorophenyl) cyclohexyl)methyl p-toluenesulfonate and (trans-4-n-propyl4-silacyclohexyl)methylmagnesium bromide.

Sources & evidence

ORD record
ord-68ec570df49748838d992f2e725e3ca7
Source dataset
uspto-grants-1996_08
Patent number
US05547606

Reaction notes

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