HCID 178448079, compound → HCID 178445824, compound

HRID 1078169Notes

Reaction equation

HRID 1078169 reaction equation
I[CH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH2:5][CH2:4]1.I[CH2:17][C@H]1CC[C@H](CCC)CC1.FC1[CH:33]=[CH:32][C:31]([CH:34]2[CH2:39][CH2:38][SiH:37]([CH2:40][Mg]Cl)[CH2:36][CH2:35]2)=CC=1>>[CH2:31]([C@H:34]1[CH2:35][CH2:36][Si@H:37]([CH2:40][CH2:2][C@H:3]2[CH2:8][CH2:7][C@H:6]([C:9]3[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=3)[CH2:5][CH2:4]2)[CH2:38][CH2:39]1)[CH:32]([CH3:33])[CH3:17]

Participants

4

Reactant 3

HCID 178448079HCID 178448079, compoundHCID 178505522HCID 178505522, compoundHCID 178505739HCID 178505739, compound

Product 1

HCID 178445824HCID 178445824, compound

Procedure

The preparation was conducted in the same manner as in Example 30, except that 6.3 g (19.9 mmol) of trans-1-iodomethyl-4-(p-fluorophenyl)cyclohexane and (4-n-isobutyl-1-silacyclohexyl) methylmagnesium chloride were used instead of 4.5 g (19.9 mmol) of trans-1-iodomethyl-4-n-propylcyclohexane and (4-(p-fluorophenyl)-1-silacyclohexyl)methylmagnesium chloride.

Sources & evidence

ORD record
ord-d748e4b8e7b843e2bb5c2505642cb974
Source dataset
uspto-grants-1996_08
Patent number
US05547606

Reaction notes

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