HCID 178439194, compound → HCID 178439122, compound

HRID 1078171Notes

Reaction equation

HRID 1078171 reaction equation
Br[CH:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][C@H:10]2[CH2:15][CH2:14][Si@H:13]([CH2:16][CH2:17][CH3:18])[CH2:12][CH2:11]2)[CH2:4][CH2:3]1.[CH2:19]([C:22]1[CH:27]=[CH:26][C:25]([Mg]Br)=[CH:24][CH:23]=1)[CH2:20][CH3:21].Cl[SiH]1CCC(CC[C@H]2CC[C@H](CCCCC)CC2)CC1.FC1C=C([Mg]Br)C=CC=1F>>[CH2:19]([C:22]1[CH:27]=[CH:26][C:25]([C@H:2]2[CH2:7][CH2:6][C@H:5]([CH2:8][CH2:9][C@H:10]3[CH2:15][CH2:14][Si@H:13]([CH2:16][CH2:17][CH3:18])[CH2:12][CH2:11]3)[CH2:4][CH2:3]2)=[CH:24][CH:23]=1)[CH2:20][CH3:21]

Participants

5

Reactant 4

HCID 178439194HCID 178439194, compoundHCID 178444430HCID 178444430, compoundHCID 178460929HCID 178460929, compoundHCID 178505835HCID 178505835, compound

Product 1

HCID 178439122HCID 178439122, compound

Procedure

The preparation was conducted in the same manner as in Example 33, except that 2.6 g (7.9 mmol) of 1-bromo-4-(2-(trans-4-n-propyl-4-silacyclohexyl)ethyl)cyclohexane and p-n-propylphenylmagnesium bromide were used instead of 2.5 g (7.9 mmol) of 1-chloro-4-(2-(trans-4-n-pentylcyclohexyl) ethyl)-1-silacyclohexane and 3,4-difluorophenylmagnesium bromide.

Sources & evidence

ORD record
ord-779f26344541414ea2369d3e8d1a11c3
Source dataset
uspto-grants-1996_08
Patent number
US05547606

Reaction notes

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