反应详情

Acetic anhydride (5.8 ml) and triethylamine (2.1 ml) were added to 2-(3,5-di-tert.-butyl-4-hydroxybenzylidene)-3,4-dihydro-3-oxo-4-(1H-tetrazol-5-ylmethyl)-2H-1,4-benzothiazine (compound No. 2-1, 0.32 g) and the mixture was refluxed overnight. To the mixture, dilute hydrochloric acid was added and the whole was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo. The oily residue was purified by silica gel column chromatography to give the titled compound.

1. temperature2-1, 0.32 g) and the mixture was refluxed overnight
2. extractionthe whole was extracted with ethyl acetate
3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
4. concentrationconcentrated in vacuo
5. customThe oily residue was purified by silica gel column chromatography