Potassium Carbonate → 2-Amino-5-(6-chloro-2,2-dimethyl-1,3-benzodioxol-4-yl)-4-methyl-3-pyridinecarbonitrile

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Reaction Steps

This compound is prepared in a manner analogous to that of Step D of Example 4, using 1.7 grams (0.008 mole) of 2-amino-5-bromo-3-cyano-4-methylpyridine, 2.7 grams (0.012 mole) of 5-chloro-2,2-dimethylbenzodioxolan-7-ylboronic acid, 4.3 grams (0.031 mole) of potassium carbonate and 0.3 gram of tetrakis(triphenylphosphine)palladium(0) in 150 mL of toluene, yielding 2-amino-3-cyano-4-methyl-5-(5-chloro-2,2-dimethylbenzodioxolan-7-yl)pyridine.

Provenance & Evidence