反应详情

To a mixture of 370 ml of conc. sulfuric acid and 61.2 ml of 70% nitric acid, 36.6 g of 2,4,5-trifluoro-3-methylbenzoic acid was added at 55° to 70° C. by portions with stirring. After 2 hours at room temperature, the reaction mixture was poured into ice and extracted with isopropyl ether. The combined extracts were washed with brine, dried and evaporated to give 30.6 g of the desired compound as yellow crystals.

1. additionwas added at 55° to 70° C. by portions
2. additionthe reaction mixture was poured into ice
3. extractionextracted with isopropyl ether
4. washThe combined extracts were washed with brine
5. customdried
6. customevaporated