Hydrochloric Acid → HCID 9951478, compound

Participants

Reaction Steps

A mixture of 2.00 g of 5-amino-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methyl-7-(cis-4-methyl-3-trifluoroacetylamino-1-pyrrolidinyl)-4-oxoquinoline-3-carboxylic acid, 1.40 g of potassium hydroxide and 14 ml of water was stirred at room temperature for 1 hour, and then neutralized with 10% aqueous hydrochloric acid to pH 8. The deposited crystals were collected by filtration and washed with water, isopropanol and diethyl ether to give 1.65 g of the desired compound as yellow crystals. The crystals were subsequently recrystallized from a mixture of methylene chloride and methanol and 1.32 g of yellow prisms, m.p. 213.5°-215° C. were obtained.

Provenance & Evidence