Water → HCID 57282319, compound

Participants

Reaction Steps

After dissolving 10.0 g (29.4 mmoles) of 21-hydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione in 100 ml of tetrahydrofuran, 7.14 ml (51.4 mmoles) of triethylamine, then at 0° C. 13.1 g (51.4 mmoles) of 4-bromobenzenesulfonyl chloride are added to the above solution and the reaction mixture is stirred at room temperature for 4 hours, then dropwise added to 450 ml of water while stirring. The precipitate is filtered off, dried and recrystallized from ether to give the title compound in a yield of 11.0 g (67.07%), m.p.:124°-129° C.

Provenance & Evidence