反应详情

A solution of 26.0 g (87.25 mmoles) of 4,6-dichloro-2-(1-adamantylamino)pyrimidine and 39.5 g (261.6 mmoles) of 1-aminoadamantane in 200 ml of n-butanol, the reaction mixture is boiled under reflux for 24 hours, and evaporated. The residue is suspended in 400 ml of ether and filtered off. After drying, the filtered-off residue is purified by chromatography on a silica gel column and eluted with chloroform. After recrystallization from ether, the title compound is obtained in a yield of 23.94 g (66.44%), m.p.: 232°-236° C.

1. temperatureunder reflux for 24 hours
2. customevaporated
3. filtrationfiltered off
4. customAfter drying
5. customthe filtered-off residue is purified by chromatography on a silica gel column
6. washeluted with chloroform
7. customAfter recrystallization from ether