HCID 19428552, compound → HCID 67770161, compound

HRID 1078290Notes

Reaction equation

BrC1C=CC(S(O[CH2:12][C:13](=[O:35])[C@@H:14]2[C@:31]3([CH3:32])[C@H:17]([C@H:18]4[C:28](=[CH:29][CH2:30]3)[C@:26]3([CH3:27])[C:21](=[CH:22][C:23](=[O:33])[CH:24]=[CH:25]3)[CH2:20][CH2:19]4)[CH2:16][C@H:15]2[CH3:34])(=O)=O)=CC=1.[C:36]12([NH:46][C:47]3[N:52]=[C:51]([N:53]4[CH2:58][CH2:57][NH:56][CH2:55][CH2:54]4)[CH:50]=[C:49]([N:59]4[CH2:63][CH2:62][CH2:61][CH2:60]4)[N:48]=3)[CH2:45][CH:40]3[CH2:41][CH:42]([CH2:44][CH:38]([CH2:39]3)[CH2:37]1)[CH2:43]2>>[C:36]12([NH:46][C:47]3[N:52]=[C:51]([N:53]4[CH2:54][CH2:55][N:56]([CH2:12][C:13](=[O:35])[C@@H:14]5[C@:31]6([CH3:32])[C@H:17]([C@H:18]7[C:28](=[CH:29][CH2:30]6)[C@:26]6([CH3:27])[C:21](=[CH:22][C:23](=[O:33])[CH:24]=[CH:25]6)[CH2:20][CH2:19]7)[CH2:16][C@H:15]5[CH3:34])[CH2:57][CH2:58]4)[CH:50]=[C:49]([N:59]4[CH2:63][CH2:62][CH2:61][CH2:60]4)[N:48]=3)[CH2:45][CH:40]3[CH2:41][CH:42]([CH2:44][CH:38]([CH2:39]3)[CH2:37]1)[CH2:43]2

Participants

Reactant 2

HCID 19428552HCID 19428552, compound

HCID 57282319HCID 57282319, compound

Product 1

HCID 67770161HCID 67770161, compoundYield 79.94%

Procedure

The reaction of 21-(4-bromobenzenesulfonyloxy)-16α-methylpregna-1,4,9(11)-triene-3,20-dione with 2-(1-adamantylamino)-4-(1-piperazinyl)-6-pyrrolidinopyrimidine as described in Example 6 gives the title compound in a yield of 79.94%, m.p.:155°-172° C.

Sources & evidence

ORD record: ord-22ab06d431444c61bf79c78ee9b4964c
Source dataset: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05547949

Reaction notes

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