HCID 19428507, compound → HCID 67769700, compound

HRID 1078310Notes

Reaction equation

BrC1C=CC(S(O[CH2:12][C:13](=[O:35])[C@@H:14]2[C@:31]3([CH3:32])[C@H:17]([C@H:18]4[C:28](=[CH:29][CH2:30]3)[C@:26]3([CH3:27])[C:21](=[CH:22][C:23](=[O:33])[CH:24]=[CH:25]3)[CH2:20][CH2:19]4)[CH2:16][C@H:15]2[CH3:34])(=O)=O)=CC=1.[CH:36]1([NH:41][C:42]2[N:47]=[C:46]([NH:48][CH:49]3[CH2:53][CH2:52][CH2:51][CH2:50]3)[CH:45]=[C:44]([N:54]3[CH2:59][CH2:58][NH:57][CH2:56][CH2:55]3)[N:43]=2)[CH2:40][CH2:39][CH2:38][CH2:37]1>>[CH:36]1([NH:41][C:42]2[N:47]=[C:46]([NH:48][CH:49]3[CH2:50][CH2:51][CH2:52][CH2:53]3)[CH:45]=[C:44]([N:54]3[CH2:59][CH2:58][N:57]([CH2:12][C:13](=[O:35])[C@@H:14]4[C@:31]5([CH3:32])[C@H:17]([C@H:18]6[C:28](=[CH:29][CH2:30]5)[C@:26]5([CH3:27])[C:21](=[CH:22][C:23](=[O:33])[CH:24]=[CH:25]5)[CH2:20][CH2:19]6)[CH2:16][C@H:15]4[CH3:34])[CH2:56][CH2:55]3)[N:43]=2)[CH2:37][CH2:38][CH2:39][CH2:40]1

Participants

Reactant 2

HCID 19428507HCID 19428507, compound

HCID 57282319HCID 57282319, compound

Product 1

HCID 67769700HCID 67769700, compoundYield 73.1%

Procedure

21-(4-Bromobenzenesulfonyloxy)-16α-methyl-pregna-1,4,9(11)-triene-3,20-dione is reacted with 2,4-bis(cyclopentylamino)-6-(1-piperazinyl)pyrimidine according to the method of Example 6 to obtain the title compound in a yield of 73.1%, m.p.:180°-185° C.

Sources & evidence

ORD record: ord-c857bd23ec92429fb64b1a993d025e0e
Source dataset: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05547949

Reaction notes

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