P-Chloroacetophenone → HCID 19429416, compound

Participants

Reaction Steps

A mixture of 3-(4-methyl-2-phenylimidazol-1-yl)propyl-amine (5.3 g) and 4'-chloroacetophenone (3.8 g) was heated at 120°-125° C. for 7 hours. On cooling, the oil was dissolved in absolute alcohol (70 ml) and, after the addition of sodium borohydride (7.0 g), the mixture was boiled under reflux for 16 hours. Work-up as described in Example 3 gave an oil which was distilled at 185°-205° C. (0.06 mmHg). The main fraction was redistilled to give N-[1-(4-chlorophenyl)ethyl]-3-(4-methyl-2-phenyl-imidazol-1-yl)propylamine, b.p. 205° C. (0.04 mmHg). Glc indicated the presence of 14% of N-[1-(4-chlorophenyl)-ethyl]-3(5-methyl-2-phenylimidazol-1-yl)propylamine.

Provenance & Evidence