Borane;tetrahydrofuran → HCID 19429530, compound

Participants

Reaction Steps

In a similar manner to Example 52d, N-[1-(4-chlorophenyl)ethyl]-3-(imidazol-1-yl)-2,2-dimethylpropionamide (4.0 g) in THF (100 ml) was treated with BH3/THF (52.1 ml, 1M) to give an oil which was distilled at 165° C. (0.05 mmHg) and the lower boiling fraction redistilled to give N-[1-(4-chlorophenyl)ethyl]-3-(imidazol-1-yl)-2,2-dimethylpropylamine, b.p. 160° C. (0.03 mmHg).

Provenance & Evidence