HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propionamide | HCID 19429536 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propionamide | HCID 19429499 | — |
Reaction Steps
In a similar manner to Example 52c a mixture of imidazole (1.05 g) and sodium hydride (0.63 g, 60% dispersion) in THF (35 ml) was treated with 3-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propionamide (4.0 g) in THF (15 ml) to give N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propionamide which was used directly in part (c).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05547972 |
| Source dataset | uspto-grants-1996_08 |
| ORD ID | ord-ad850db23b2c4cee8e61cc5ec0bd31ca |
| Source note | uspto-grants-1996_08 |