2-Methylimidazole → HCID 23207985, compound

Participants

Reaction Steps

In a similar manner to Example 70, 5-chloro-N-(4-chlorobenzyl)valeramide (10.3 g, prepared from 4-chlorobenzylamine and 5-chlorovaleryl chloride) and 2-methylimidazole (6.5 g) were reacted together to give N-(4-chlorobenzyl)-5-(2-methylimidazol-1-yl) valeramide, (6.5 g) , m.p. 72°-75° C. which was reduced with borane/THF (86 ml, 1M) to give N-(4-chlorobenzyl)-5-(2-methylimidazol-1-yl)pentylamine, b.p. 170°-185° C. (0.1 mmHg).

Provenance & Evidence