Formaldehyde → HCID 19429427, compound

HRID 1078400Notes

Reaction equation

HRID 1078400 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][NH:7][CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[C:12]2[CH3:16])=[CH:4][CH:3]=1.[CH2:19]=O>C(O)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[C:12]2[CH3:16])[CH3:19])=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 19429371HCID 19429371, compound

Product 1

HCID 19429427HCID 19429427, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

In a similar manner to Example 90, N-(4-chlorobenzyl)-3-(2-methylimidazol-1-yl)propylamine was treated with formaldehyde and formic acid to give N-(4-chlorobenzyl)-N-methyl-3-(2-methylimidazol-1-yl)propylamine, b.p. 160°-166° C. (0.2 mmHg).

Sources & evidence

ORD record
ord-e4fa8f23d51a469a847f50a69667eaef
Source dataset
uspto-grants-1996_08
Patent number
US05547972

Reaction notes

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