Borane;tetrahydrofuran → HCID 19429411, compound

Participants

Reaction Steps

In a similar manner to Example 64b, a mixture of ethyl 1-{N-[1-(4-chlorophenyl)-1-methylethyl]-2carbamoylethyl}-5-methylimidazole-4-carboxylate (28.8 g, from Example 78) and borane/THF (303.4 ml, 400 ml THF, 1.0M solution) gave 1-{3-[1-(4-chlorophenyl)-1-methylethylamino]propyl}-5-methylimidazol-4-yl-methanol, m.p. 97°-99° C.

Provenance & Evidence