Acetyl chloride → Hydrochloric Acid

Participants

Reaction Conditions

Reaction Steps

A solution of acetyl chloride (0.24 ml) in dichloromethane (6 ml) was added dropwise to a solution of 1-[3-(1-ethyl-1-phenylpropylamino)propyl]imidazol-4-yl-methanol (10 g, from Example 86b) in dichloromethane (18 ml) containing triethylamine (0.46 ml), with stirring, at 0° C. The mixture was stirred at 0° C. for 30 minutes and then at ambient temperature for 2 hours. Work-up as described in Example 98b, but without treatment with ethereal hydrogen chloride, gave 1-[3-(α,α-diethylbenzylamino)propyl]imidazol-4-ylmethyl acetate as an oil.

Provenance & Evidence