tert-BUTYL CHLORIDE → (2E)-2-[2-(4-tert-butylphenoxy)phenyl]-2-methoxyimino-N-methylacetamide

Participants

Reaction Steps

To a solution of (E)-N-methyl-2-(2-phenoxyphenyl)2-methoxyiminoacetamide (300 mg) in nitromethane (3 ml), aluminium chloride (423 mg) and t-butyl chloride (147 mg) were added, followed by stirring at room temperature for 1 hour. The reaction mixture was diluted with water and extracted with diethyl ether. The solvent was dried and evaporated, and the residue was purified by silica gel column chromatography with a mixture of hexane and ethyl acetate to give 375 mg of the objective compound.

Provenance & Evidence