Benzyl 6-[3-(1-adamantyl)-4-methoxycarbonylmethyloxyphenyl]-2-naphthoate → 6-[3-(1-Adamantyl)-4-methoxycarbonylmethyloxyphenyl]-2-naphthoic acid

Beteiligte Stoffe

Reaktionsschritte

4.24 g (7.58 mmol) of the diester obtained in Example 4 in solution in the dioxane/acetic acid mixture (99/1) are treated with 800 mg of Pd-C (10%) at a pressure of 7 bar of hydrogen at 40° C. for 6 h. The reaction medium is then filtered on celite, evaporated, washed with water and recrystallized from the acetate/tetrahydrofuran mixture. 2.94 g (82%) of a solid are isolated, which solid melts at 283°-285° C.

Herkunft & Nachweise