反应详情

温度

100 °C

0.57 g (1.21 mmol) of the ester obtained in Example 7 in suspension in 30 ml of n-butanol is treated with 400 mg of potassium hydroxide. The reaction mixture is heated for 3 h at 100° C., then evaporated to dryness, and is taken up in 50 ml of water and washed with ether. The aqueous phase is acidified to pH=1 with concentrated HCl and extracted with 600 ml of ether. The organic phase is washed with water, dried over magnesium sulphate, filtered and evaporated to give 0.49 g (90%) of the expected acid which melts at 277°-279° C.

1. customevaporated to dryness
2. washwashed with ether
3. extractionextracted with 600 ml of ether
4. washThe organic phase is washed with water
5. dry with materialdried over magnesium sulphate
6. filtrationfiltered
7. customevaporated