Sodium Hydroxide → HCID 9844563, compound

HRID 1078498Notes

Reaction equation

HRID 1078498 reaction equation
[C:1]12([C:11]3[CH:12]=[C:13]([C:19]4[CH:20]=[C:21]5[C:26](=[CH:27][CH:28]=4)[CH:25]=[C:24]([C:29]([O:31]C)=[O:30])[CH:23]=[CH:22]5)[CH:14]=[CH:15][C:16]=3[CH2:17][OH:18])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[OH-].[Na+]>CO>[C:1]12([C:11]3[CH:12]=[C:13]([C:19]4[CH:20]=[C:21]5[C:26](=[CH:27][CH:28]=4)[CH:25]=[C:24]([C:29]([OH:31])=[O:30])[CH:23]=[CH:22]5)[CH:14]=[CH:15][C:16]=3[CH2:17][OH:18])[CH2:2][CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:9]3)[CH2:8]1)[CH2:10]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10764915HCID 10764915, compound

Product 1

HCID 9844563HCID 9844563, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4.40 g (103 mmol) of the ester obtained in Example 11 in 50 ml of methanol are treated with 4 g of sodium hydroxide, with stirring, for 1 h 30 min. After the same treatment as in Example 8 and recrystallization from the ethanol/water mixture, 3 g (96%) of the expected product are isolated, which product melts at 267°-270° C.

Workup

  1. customAfter the same treatment as in Example 8 and recrystallization from the ethanol/water mixture, 3 g (96%) of the expected product
  2. customare isolated

Sources & evidence

ORD record
ord-6ac79f3cfd054b068491aca730a1b25b
Source dataset
uspto-grants-1996_08
Patent number
US05547983

Reaction notes

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