Sodium Hydroxide → HCID 23362738, compound

HRID 1078500Notes

Reaction equation

HRID 1078500 reaction equation
[OH-].[Na+].[C:3]12([C:13]3[CH:14]=[C:15]([C:23]4[CH:24]=[C:25]5[C:30](=[CH:31][CH:32]=4)[CH:29]=[C:28]([C:33]([O:35]C)=[O:34])[CH:27]=[CH:26]5)[CH:16]=[CH:17][C:18]=3[C:19]([O:21][CH3:22])=[O:20])[CH2:12][CH:7]3[CH2:8][CH:9]([CH2:11][CH:5]([CH2:6]3)[CH2:4]1)[CH2:10]2>CO>[C:3]12([C:13]3[CH:14]=[C:15]([C:23]4[CH:24]=[C:25]5[C:30](=[CH:31][CH:32]=4)[CH:29]=[C:28]([C:33]([OH:35])=[O:34])[CH:27]=[CH:26]5)[CH:16]=[CH:17][C:18]=3[C:19]([O:21][CH3:22])=[O:20])[CH2:12][CH:7]3[CH2:6][CH:5]([CH2:11][CH:9]([CH2:8]3)[CH2:10]1)[CH2:4]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19429734HCID 19429734, compound

Product 1

HCID 23362738HCID 23362738, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.34 g of sodium hydroxide is added to 1.92 g (4.22 mmol) of the diester obtained in Example 14 in 25 ml of methanol and the mixture is kept under reflux for 24 hours. After the same treatment as in Example 8 and recrystallization from the isopropyl ether-ethyl acetate mixture, 1.7 g (91%) of the expected derivative are isolated, which derivative melts at 272°-273° C.

Workup

  1. temperatureunder reflux for 24 hours
  2. customAfter the same treatment as in Example 8 and recrystallization from the isopropyl ether-ethyl acetate mixture, 1.7 g (91%) of the expected
  3. customderivative are isolated

Sources & evidence

ORD record
ord-69cd6a3a67414c01a4031c8abbe9189e
Source dataset
uspto-grants-1996_08
Patent number
US05547983

Reaction notes

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